Lin et al. 2023 is the most recent Cochrane Database update on HBOT for late radiation tissue injury (LRTI), succeeding Bennett et al. 2016 (pub4). The Cochrane Database of Systematic Reviews is the highest-tier evidence framework in clinical medicine, and this review pools randomized-trial evidence for HBOT in radiation-induced tissue injuries — most prominently osteoradionecrosis (bone death after head/neck radiation), radiation cystitis (bladder injury after pelvic radiation), and radiation proctitis (rectal injury after pelvic radiation). For accurate effect-size figures from the 2023 update, consult the Cochrane abstract directly via the linked PubMed entry; the prior site copy mixed numbers from earlier pub4 summaries and is being verified.
Hyperbaric oxygen therapy for late radiation tissue injury
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C
Lin et al. 2023 is the most recent Cochrane Database update on HBOT for late radiation tissue injury (LRTI), succeeding Bennett et al. 2016 (pub4). The Cochrane Database of Systematic Reviews is the highest-tier evidence framework in clinical medicine, and this review pools randomized-trial evidence for HBOT in radiation-induced tissue injuries — most prominently osteoradionecrosis (bone death after head/neck radiation), radiation cystitis (bladder injury after pelvic radiation), and radiation proctitis (rectal injury after pelvic radiation). For accurate effect-size figures from the 2023 update, consult the Cochrane abstract directly via the linked PubMed entry; the prior site copy mixed numbers from earlier pub4 summaries and is being verified.
What the trial documented.
- Cochrane systematic review of HBOT for late radiation tissue injury (LRTI)
- Pooled evidence supports HBOT for osteoradionecrosis, radiation cystitis, and radiation proctitis
- Updated 2023 review extends and supersedes Bennett 2016 (pub4)
Range across included Cochrane review trials — typically 2.0–2.4 ATA, 100% oxygen, 90-minute sessions
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database of Systematic Reviews. 2023.